Host Genetics Background Affects Intestinal Cancer Development Associated with High-Fat Diet-Induced Obesity and Type 2 Diabetes
Host genetics plays a crucial role in susceptibility to HFD-induced obesity, T2D, CRC, and inflammation. Genetic differences across CC lines contributed to variability in disease outcomes, providing insight into the genetic underpinnings of multimorbidity. This study supports gene-mapping efforts to develop personalized prevention and treatment strategies for these diseases.
Authors
- Osayd Zohud (ORCID: https://orcid.org/0000-0003-3530-1420)
- Iqbal M. Lone (ORCID: https://orcid.org/0000-0001-5292-6778)
- Arne S. Schäefer (ORCID: https://orcid.org/0000-0001-5816-6765)
- Sama Karram
- Fuad A. Iraqi (ORCID: https://orcid.org/0000-0001-5525-206X)
- Yael Houri‐Haddad
- Kareem Midlej (ORCID: https://orcid.org/0000-0003-0144-575X)
- Aya Ghnaim
Institutions
- Tel Aviv University (IL)
- Hebrew University of Jerusalem (IL)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Cells
- Published
- 2024-10-31
- DOI
- https://doi.org/10.3390/cells13211805
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Israel Science Foundation
- Tel Aviv University