Validation of the Online Collaborative Ocular Tuberculosis Study Calculator for Tubercular Uveitis
Results of this diagnostic study suggest that the COTS calculator (score ≥4) was more specific than clinician judgment for ATT initiation. Although clinician judgment is a good first step to identify all potential true positives (with high sensitivity), a second consultation with COTS-5 (with high PPV) may lead to less false positives. This tool, apt for high-prevalence, low-resource settings, recommends ATT more selectively for genuine TBU cases. Large prospective studies are essential to explore potential improvements in the calculator's sensitivity.
Authors
- İlknur Tuğal-Tutkun (ORCID: https://orcid.org/0000-0002-4020-453X)
- William Rojas‐Carabali (ORCID: https://orcid.org/0000-0002-9976-8989)
- Onn Min Kon (ORCID: https://orcid.org/0000-0003-2647-4688)
- Kalpana Babu Murthy
- John H. Kempen (ORCID: https://orcid.org/0000-0002-2967-4792)
- Nataša Vidović Valentinčič (ORCID: https://orcid.org/0000-0003-4136-8242)
- Jyotirmay Biswas (ORCID: https://orcid.org/0000-0003-1214-5429)
- Soon‐Phaik Chee (ORCID: https://orcid.org/0000-0002-6308-5721)
- Dinesh Visva Gunasekeran (ORCID: https://orcid.org/0000-0002-8502-2334)
- Alessandro Invernizzi (ORCID: https://orcid.org/0000-0003-3400-1987)
- Ludi Zhang (ORCID: https://orcid.org/0000-0003-2061-4563)
- Bety Yañez Alvarez
- Bernett Teck Kwong Lee (ORCID: https://orcid.org/0000-0002-2709-1972)
- Zheng Xian Thng (ORCID: https://orcid.org/0000-0003-3275-7537)
- Rina La Distia Nora (ORCID: https://orcid.org/0000-0002-7026-5341)
- Ester Carreño (ORCID: https://orcid.org/0000-0002-0055-9547)
- Christoph Tappeiner (ORCID: https://orcid.org/0000-0001-6907-1112)
- Ekaterina V. Denisova (ORCID: https://orcid.org/0000-0003-3735-6249)
- Manabu Mochizuki (ORCID: https://orcid.org/0000-0002-8240-4134)
- Talin Barisani‐Asenbauer (ORCID: https://orcid.org/0000-0002-8661-9183)
- Aniruddha Agarwal (ORCID: https://orcid.org/0000-0003-4985-9855)
- Amanda Yuan Ling Lim (ORCID: https://orcid.org/0000-0001-7488-0985)
- Peter McCluskey (ORCID: https://orcid.org/0000-0002-8177-1637)
- Mukesh Agrawal (ORCID: https://orcid.org/0000-0003-4747-9533)
- Sarakshi Mahajan (ORCID: https://orcid.org/0000-0001-7947-4302)
- Manohar Babu Balasundaram (ORCID: https://orcid.org/0000-0003-0384-2951)
- Piergiorgio Neri (ORCID: https://orcid.org/0000-0002-7673-4276)
- André Luiz Land Curi (ORCID: https://orcid.org/0000-0002-2764-4047)
- Romi Chhabra
- Gazal Patnaik
- Hazlita Mohd Isa (ORCID: https://orcid.org/0000-0002-2731-8233)
- Manfred Zierhut
- Laure Caspers
- Rupesh Agrawal (ORCID: https://orcid.org/0000-0002-6662-5850)
- Justine R. Smith (ORCID: https://orcid.org/0000-0002-4756-5493)
- Yan Guex Crosier
- Sofia Androudi (ORCID: https://orcid.org/0000-0002-5303-7793)
- Shahana Mazumdar
- Edoardo Baglivo
- Elisabetta Miserocchi (ORCID: https://orcid.org/0000-0003-2989-6712)
- Debra A. Goldstein
- Careen Y. Lowder (ORCID: https://orcid.org/0000-0001-6723-7238)
- Daniel Vitor Vasconcelos-Santos (ORCID: https://orcid.org/0000-0002-6747-2024)
- Ilaria Testi (ORCID: https://orcid.org/0000-0003-1711-033X)
- Vishali Gupta (ORCID: https://orcid.org/0000-0001-8216-4620)
- Shah Md. Islam
- Alastair Keith Denniston (ORCID: https://orcid.org/0000-0001-7849-0087)
- Cristina Muccioli (ORCID: https://orcid.org/0000-0002-6870-6187)
- Luz Elena Concha del Río (ORCID: https://orcid.org/0000-0002-0081-7745)
- Annabelle A. Okada (ORCID: https://orcid.org/0000-0002-8850-8962)
- Hassan Al-Dhibi (ORCID: https://orcid.org/0000-0002-0621-1234)
- Bahram Bodaghi (ORCID: https://orcid.org/0000-0002-0962-5301)
- Heloísa Nascimento (ORCID: https://orcid.org/0000-0003-0315-1317)
- Padmamalini Mahendradas (ORCID: https://orcid.org/0000-0002-6137-8870)
- Quan Dong Nguyen (ORCID: https://orcid.org/0000-0002-6024-8441)
- Samir S. Shoughy (ORCID: https://orcid.org/0000-0002-9655-0669)
- Ramandeep Singh (ORCID: https://orcid.org/0000-0001-5775-7993)
- Mark Westcott (ORCID: https://orcid.org/0000-0001-9516-1576)
- Amitabh Kumar
- Sudharshan Sridharan
- Kusum Sharma (ORCID: https://orcid.org/0009-0001-7021-654X)
- Nicholas Jones
- Moncef Khairallah
- Kanika Aggarwal (ORCID: https://orcid.org/0009-0004-4555-4418)
- Manisha Agarwal
- Jyotirmay Biswas
- Carlos Pavesio
- S. Jun
- Shobha Sehgal
- Emmett T. Cunningham
- Shannon Sheriel Choo
- Digamber Behera (ORCID: https://orcid.org/0009-0009-7708-8585)
- Andrés Rousselot
- Rupesh Agrawal
Institutions
- Agency for Science, Technology and Research (SG)
- Sankara Nethralaya (IN)
- Massachusetts Eye and Ear Infirmary (US)
- The University of Sydney (AU)
- Harvard University (US)
- Imperial College Healthcare NHS Trust (GB)
- Flinders University (AU)
- Nanyang Technological University (SG)
- Singapore Immunology Network (SG)
- Tan Tock Seng Hospital (SG)
- Khoo Teck Puat Hospital (SG)
- National Institute for Health and Care Research (GB)
- Trinity Health Oakland Hospital (US)
- Queensland Eye Institute (AU)
- St Mary's Hospital (GB)
- Collaborative Group (United States) (US)
- Singapore Eye Research Institute (SG)
- Duke-NUS Medical School (SG)
- Moorfields Eye Hospital (GB)
- St. Paul's Hospital Millennium Medical College (ET)
- NIHR Biomedical Research Centre at The Royal Marsden and the ICR
- University College London (GB)
- Post Graduate Institute of Medical Education and Research (IN)
- Addis Ababa University (ET)
- Smith-Kettlewell Eye Research Institute (US)
Publication Details
- Journal
- JAMA Ophthalmology
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1001/jamaophthalmol.2024.4567
- Citations
- 6
- Primary Topic
- Ocular Diseases and Behçet’s Syndrome
- Type
- article
- Field-Weighted Citation Impact
- 3.23