Classification of Predictors of Rapid Development of Kidney Failure and Short-Term Changes in Concentration of Circulating Proteins
Development of rapid KF in diabetes was preceded by elevated concentrations of multiple circulating proteins both at baseline and during short follow-up. Comparing baseline and short-term changes in concentrations of circulating proteins classified predictors of rapid KF risk into those associated with initiation, progression, or both. Predictors of both initiation & progression flagged apoptosis processes and TNF receptor signaling pathways. Multi-protein prognostic algorithms using proteins associated with both initiation and progression improved prediction of rapid KF risk beyond clinical variables.
Authors
- Eiichiro Satake (ORCID: https://orcid.org/0000-0002-9784-4423)
- Katsuhito Ihara (ORCID: https://orcid.org/0000-0001-9554-3646)
- Hiroki Hill Kobayashi (ORCID: https://orcid.org/0000-0002-9674-0374)
- Zaipul I. Md Dom (ORCID: https://orcid.org/0000-0003-3503-7391)
- Alessandro Doria (ORCID: https://orcid.org/0000-0002-3830-4304)
- Sok Cin Tye (ORCID: https://orcid.org/0000-0002-7286-1745)
- Kevin L. Duffin (ORCID: https://orcid.org/0000-0002-1656-8982)
- Andrzej S. Królewski (ORCID: https://orcid.org/0000-0002-1705-2953)
- Helen C. Looker (ORCID: https://orcid.org/0000-0002-0802-781X)
- Robert G. Nelson (ORCID: https://orcid.org/0000-0001-7307-3786)
Institutions
- Nihon University (JP)
- Joslin Diabetes Center (US)
- Harvard University (US)
- Eli Lilly (United States) (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
Publication Details
- Journal
- Clinical Journal of the American Society of Nephrology
- Published
- 2024-10-31
- DOI
- https://doi.org/10.2215/cjn.0000000603
- Citations
- 2
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.68
Funders
- Foundation for the National Institutes of Health
- American Diabetes Association Research Foundation
- Uehara Memorial Foundation
- NoVo Foundation
- Japan Society for the Promotion of Science