Ononin delays the development of osteoarthritis by down-regulating MAPK and NF-κB pathways in rat models
Our results demonstrated that ononin may ameliorate cartilage damage and inflammatory response in OA rats by downgrading MAPK and NF-κB pathways, thus identifying ononin as a potential novel drug to treat OA.
Authors
- Michael Aschner (ORCID: https://orcid.org/0000-0002-2619-1656)
- Zhao-cong Li
- Yue‐Ming Jiang (ORCID: https://orcid.org/0000-0001-5123-3072)
- Xu Fang (ORCID: https://orcid.org/0000-0002-4614-9279)
- Ting Liao (ORCID: https://orcid.org/0000-0001-8298-2359)
- Qingjun Wei (ORCID: https://orcid.org/0009-0006-7190-6469)
Institutions
- Albert Einstein College of Medicine (US)
- Guangxi Medical University (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1371/journal.pone.0310293
- Citations
- 5
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.35
Funders
- Guangxi Key Research and Development Program