Protocol for a double-blind crossover randomised controlled trial to investigate inhalation challenge to assess inducible laryngeal obstruction: CH-ILO
This will be the first randomised controlled trial to investigate the role of inhalation challenge as an assessment tool to evoke laryngeal obstruction in patients with confirmed ILO. If results prove CA inhalation challenge agent provokes ILO, it will provide new insights into neuronal mechanisms and support development of a standardised diagnostic test.
Authors
- Eric Dubuis (ORCID: https://orcid.org/0000-0001-7658-4178)
- John A. Smith (ORCID: https://orcid.org/0000-0001-8837-4928)
- Maria G. Belvisi (ORCID: https://orcid.org/0000-0003-1652-4370)
- Janelle Yorke (ORCID: https://orcid.org/0000-0002-1344-5944)
- Stephen James Fowler (ORCID: https://orcid.org/0000-0002-4524-1663)
- Jemma Haines (ORCID: https://orcid.org/0000-0003-3813-041X)
- Kimberley Holt (ORCID: https://orcid.org/0000-0003-0413-8085)
- James H. Hull (ORCID: https://orcid.org/0000-0003-4697-1526)
- Rachel Dockry (ORCID: https://orcid.org/0000-0002-0908-3362)
Institutions
- Hong Kong Polytechnic University (HK)
- English Institute of Sport (GB)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- Manchester University NHS Foundation Trust (GB)
- Royal Brompton Hospital (GB)
- AstraZeneca (Netherlands) (NL)
- AstraZeneca (Finland) (FI)
- NIHR Manchester Biomedical Research Centre (GB)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1183/23120541.00774-2024
- Citations
- 2
- Primary Topic
- Voice and Speech Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.65