(−)-Epicatechin regulates endoplasmic reticulum stress and promotes ferroptosis in lung cancer cells via the PERK/eIF2α/ATF4 signaling pathway
EC therapy activates the PERK-eIF2α-ATF4 signaling pathway to increase ER stress, thereby promoting ferroptosis in lung cancer cells and inhibiting the occurrence and development of lung cancer. Our research suggests that EC may become a drug candidate for treating lung cancer.
Authors
- Jianhua Ji (ORCID: https://orcid.org/0000-0002-3669-4548)
- Peiwan Liu (ORCID: https://orcid.org/0000-0003-3745-0323)
- Yingyu Yang (ORCID: https://orcid.org/0009-0006-3492-705X)
- Yunkui Yang
- Wen-Sheng Huang (ORCID: https://orcid.org/0000-0002-2320-452X)
- Liqiong Zhang (ORCID: https://orcid.org/0000-0002-1754-136X)
- Wenhui Li (ORCID: https://orcid.org/0000-0001-5080-1111)
- Zhijun Zhang (ORCID: https://orcid.org/0000-0003-3055-3426)
- Zengbo Lv
- Anao Wu
- Meifang Huang (ORCID: https://orcid.org/0000-0002-4230-493X)
Institutions
- Kunming Medical University (CN)
- Qujing Normal University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1371/journal.pone.0313010
- Citations
- 8
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.35
Funders
- National Natural Science Foundation of China