Molecular mechanism underlying the protective effects of ischemic preconditioning in total knee arthroplasty
Iron-sulfur cluster scaffold may promote IPC-induced ischemic tolerance mediated by alpha-2-macroglobulin antisense RNA 1-miR-7161-5p axis. Moreover, IPC may induce a protective response after total knee arthroplasty via mitochondria-related functions and the carbon metabolism pathway, which should be further validated in the near future.
Authors
- Xueliang Han
- Yong-li WANG
- Bencai Du
- Lianjun Qu (ORCID: https://orcid.org/0000-0001-7259-8978)
Institutions
- Union Hospital (HK)
- People's Liberation Army 401 Hospital (CN)
- Chinese People's Liberation Army (CN)
Publication Details
- Journal
- Chinese Journal of Traumatology
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1016/j.cjtee.2024.02.007
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00