A comprehensive item bank of internal validity issues of relevance to in vitro toxicology studies
To our knowledge, this is the second item bank of any kind to have been created for toxicology studies, and the first to use focus groups as a data source alongside literature analysis. The large number of items contributed by focus group discussions suggests this is an efficient method for capturing internal validity issues that are not easily identifiable in the literature. We believe our item bank and methodology for its creation will be a useful resource for supporting the development of appraisal tools. Due to the broad applicability of many items in the item bank, it may be informative for study designs beyond the <i>in vitro</i> domain.
Authors
- Trine Husøy (ORCID: https://orcid.org/0000-0002-2827-7111)
- Heather Ames (ORCID: https://orcid.org/0000-0001-8509-7160)
- Erwin Roggen (ORCID: https://orcid.org/0000-0002-9371-8390)
- Gunn Elisabeth Vist (ORCID: https://orcid.org/0000-0001-7764-2501)
- Pilar Prieto (ORCID: https://orcid.org/0000-0002-9275-6248)
- Gro Haarklou Mathisen (ORCID: https://orcid.org/0000-0003-3824-4898)
- Andrew A. Rooney (ORCID: https://orcid.org/0000-0002-1756-5185)
- Paul Whaley (ORCID: https://orcid.org/0000-0003-4021-0785)
- Camilla Svendsen (ORCID: https://orcid.org/0000-0002-3216-0469)
- Joshua F. Robinson (ORCID: https://orcid.org/0000-0002-2421-4535)
- Olga Tcheremenskaia (ORCID: https://orcid.org/0000-0002-5029-3484)
- Ingrid L. Druwe (ORCID: https://orcid.org/0000-0002-0591-0295)
- Nicolas Roth (ORCID: https://orcid.org/0000-0002-2917-4384)
- Mathieu Vinken (ORCID: https://orcid.org/0000-0001-5115-8893)
- Eliana Spilioti (ORCID: https://orcid.org/0000-0002-0441-7466)
- Sebastian Hoffmann (ORCID: https://orcid.org/0000-0002-3214-7678)
- Anastasia Spyropoulou (ORCID: https://orcid.org/0000-0001-8599-7740)
- Carlijn R. Hooijmans (ORCID: https://orcid.org/0000-0001-6435-5714)
- Kyriaki Machera (ORCID: https://orcid.org/0000-0001-6499-3468)
- Emanuela Testai (ORCID: https://orcid.org/0000-0003-3113-5103)
- Anna Beronius (ORCID: https://orcid.org/0000-0001-9494-5395)
- Thomas Härtung (ORCID: https://orcid.org/0000-0003-1359-7689)
- Emma Di Consiglio (ORCID: https://orcid.org/0000-0001-5575-0376)
Institutions
- Environmental Protection Agency (US)
- Norwegian Institute of Public Health (NO)
- Istituto Nazionale di Statistica (IT)
- Vrije Universiteit Brussel (BE)
- Johns Hopkins University (US)
- Radboud University Nijmegen (NL)
- University of California, San Francisco (US)
- Environmental Protection Agency (GH)
- University of Basel (CH)
- University of Konstanz (DE)
- European Commission (BE)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- Karolinska Institutet (SE)
- Triangle (US)
- National Institute of Environmental Health Sciences (US)
- Joint Research Centre (IT)
- National Institute of Health (AM)
- Benaki Phytopathological Institute (GR)
- ABS Consulting (United States) (US)
- BH Consulting (Ireland) (IE)
- Pharmac (NZ)
- Environmental Protection Agency (IE)
- Swiss Centre for Applied Human Toxicology
- Lancaster University (GB)
Publication Details
- Journal
- Evidence-Based Toxicology
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1080/2833373x.2024.2418045
- Citations
- 1
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.71
Funders
- University of New South Wales
- Staatssekretariat für Bildung, Forschung und Innovation
- Norwegian Institute of Public Health