Engineering a Digital Twin for Diagnosis and Treatment of Multiple Sclerosis

Multiple sclerosis (MS) is a complex, chronic, and heterogeneous disease of the central nervous system that affects 3 million people globally. The multifactorial nature of MS necessitates an adaptive and personalized approach to diagnosis, monitoring, and treatment. This paper proposes a novel Digital Twin for Multiple Sclerosis (DTMS) designed to integrate diverse data sources, including Magnetic resonance imaging (MRI), clinical biomarkers, and digital health metrics, into a unified predictive model. The DTMS aims to enhance the precision of MS management by providing real-time, individualized insights into disease progression and treatment efficacy. Through a federated learning approach, the DTMS leverages explainable AI to offer reliable and personalized therapeutic recommendations, ultimately striving to delay disability and improve patient outcomes. This comprehensive digital framework represents a significant advancement in the application of AI and digital twins in the field of neurology, promising a more tailored and effective management strategy for MS.