Homeostatic signals, including IL-7 and self-MHC recognition, induce the development of peripheral helper T cells, which are enriched in the joints of rheumatoid arthritis
Our results demonstrate an antigen-nonspecific developmental pathway of Tph cells triggered by homeostatic signals and promoted by the local environment of RA, which accounts for the accumulation of Tph cells in inflamed joints.
Authors
- Motoki Yoshimura
- Hisakata Yamada (ORCID: https://orcid.org/0000-0002-6329-7222)
- Shinya Kawahara (ORCID: https://orcid.org/0000-0001-9229-6205)
- Yuya Kunisaki (ORCID: https://orcid.org/0000-0003-0141-7038)
- Hiroaki Niiro (ORCID: https://orcid.org/0000-0003-0914-9066)
- Yukio Akasaki (ORCID: https://orcid.org/0000-0002-3666-3952)
- Takashi Natori
- Ryosuke Tsurui (ORCID: https://orcid.org/0009-0007-9643-7395)
- Yasuharu Nakashima
Institutions
- Kyushu University (JP)
Publication Details
- Journal
- Journal of Translational Autoimmunity
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1016/j.jtauto.2024.100258
- Citations
- 1
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.24