Cerebral Amyloid Angiopathy, Dementia, and Alzheimer Neuropathologic Changes
We observed a significant association between CAA and dementia that disappeared when adjusted for CERAD or Braak stages. Findings from our mediation analyses suggest that the CAA-dementia association may be potentially mediated by AD neuropathologic changes. This hypothesis needs to be tested in future mechanistic studies in AD accounting for unmeasured confounders.
Authors
- N. Maritza Dowling
- Mo‐Kyung Sin
- Edward Zamrini (ORCID: https://orcid.org/0000-0002-3685-4580)
- Ali Ahmed (ORCID: https://orcid.org/0000-0002-6832-6424)
- Yan Cheng (ORCID: https://orcid.org/0000-0002-7905-0443)
- Jeffrey M. Roseman
Institutions
- Washington University Medical Center (US)
Publication Details
- Journal
- Neurology
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1212/wnl.0000000000210009
- Citations
- 7
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- National Institutes of Health