Synthesis of C–N or C–C Spiroindolines via Rearrangement Coupling Reaction

Herein, we report a general approach to effectively construct C-N or C-C spiroindolines using tetrahydro-β-carbolines as starting materials via a rearrangement coupling reaction. This method is characterized by its operational simplicity and mild conditions. Notably, a wide range of anilines and indoles are suitable for this intermolecular coupling, yielding the corresponding C-N or C-C spiroindolines in good to excellent yields.

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Publication Details

Journal
Organic Letters
Published
2024-10-31
DOI
https://doi.org/10.1021/acs.orglett.4c03644
Citations
2
Primary Topic
Asymmetric Synthesis and Catalysis
Type
article
Field-Weighted Citation Impact
0.50

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article

Synthesis of C–N or C–C Spiroindolines via Rearrangement Coupling Reaction

Xiao‐Ling Liu, Yu Gao, Panpan Qiao, Hui Chen et al.
2 citations
Organic Letters
Asymmetric Synthesis and Catalysis
0.50
article

Synthesis of C–N or C–C Spiroindolines via Rearrangement Coupling Reaction

Xiao‐Ling Liu, Yu Gao, Panpan Qiao, Hui Chen, Haijun Chen
article en
2 citations

Abstract

Herein, we report a general approach to effectively construct C-N or C-C spiroindolines using tetrahydro-β-carbolines as starting materials via a rearrangement coupling reaction. This method is characterized by its operational simplicity and mild conditions. Notably, a wide range of anilines and indoles are suitable for this intermolecular coupling, yielding the corresponding C-N or C-C spiroindolines in good to excellent yields.

Organic LettersVol. 26(45)
Fuzhou University (CN)
Natural Science Foundation of Fujian Province, China National Funds for Distinguished Young Scientists
Openalex Percentile: Top 38%
Asymmetric Synthesis and Catalysis
0.50
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