Large-Scale Pharmacogenomics Analysis of Patients With Cancer Within the 100,000 Genomes Project Combining Whole-Genome Sequencing and Medical Records to Inform Clinical Practice
Reporting PGx variants from germline WGS relevant to patients with cancer alongside primary findings related to their cancer can be clinically informative, informing prescribing to reduce the risk of ADRs. Extending the range of actionable variants to those found in patients of non-European ancestry is important and will extend the potential clinical impact.
Authors
- Matthew A. Brown (ORCID: https://orcid.org/0000-0003-0538-8211)
- Nirupa Murugaesu (ORCID: https://orcid.org/0000-0002-5005-7908)
- Susan Walker (ORCID: https://orcid.org/0000-0002-5016-6426)
- Olivia Niblock
- Sue Hill
- Eleanor Williams (ORCID: https://orcid.org/0000-0002-0851-7990)
- Richard H. Scott (ORCID: https://orcid.org/0000-0002-9113-2978)
- Louise C. Daugherty (ORCID: https://orcid.org/0000-0003-4546-6667)
- Ivone Leong (ORCID: https://orcid.org/0000-0002-0831-3461)
- Greg Elgar (ORCID: https://orcid.org/0000-0001-7323-1596)
- Loukas Moutsianas (ORCID: https://orcid.org/0000-0001-5453-345X)
- Catherine Snow (ORCID: https://orcid.org/0000-0002-1672-3532)
- Alexander Stuckey (ORCID: https://orcid.org/0000-0001-8636-737X)
- Adam Giess (ORCID: https://orcid.org/0000-0003-1683-2146)
- Marta Bleda (ORCID: https://orcid.org/0000-0002-1287-6013)
- Ellen M. McDonagh (ORCID: https://orcid.org/0000-0001-5806-6174)
- Claudia Cabrera (ORCID: https://orcid.org/0000-0002-2205-5315)
- Sonali Sanghvi (ORCID: https://orcid.org/0000-0002-1937-5430)
- Augusto Rendon (ORCID: https://orcid.org/0000-0001-8994-0039)
- S. E. A. Leigh (ORCID: https://orcid.org/0000-0003-3368-7059)
- Christopher A. Odhams (ORCID: https://orcid.org/0000-0003-2396-6150)
- Alona Sosinsky (ORCID: https://orcid.org/0000-0001-9022-7409)
- G. C. Chan
- Zandra C. Deans (ORCID: https://orcid.org/0000-0001-9361-6012)
- Mark J. Caulfield (ORCID: https://orcid.org/0000-0001-9295-3594)
- Rebecca E. Foulger (ORCID: https://orcid.org/0000-0001-8682-8754)
- M. J. Welland (ORCID: https://orcid.org/0000-0001-5963-863X)
- Richard M. Turner (ORCID: https://orcid.org/0000-0002-7315-679X)
- Amanda R. Pickard
- Daniel R. Rhodes (ORCID: https://orcid.org/0000-0002-2021-4773)
- Paul J. Ross (ORCID: https://orcid.org/0000-0002-2390-1886)
- Valentina Cipriani (ORCID: https://orcid.org/0000-0002-0839-9955)
- Michael R. Barnes (ORCID: https://orcid.org/0000-0001-9097-7381)
- Dorota Pasko
- Lauren Marks
- Antonio Rueda-Martin
Institutions
- European Bioinformatics Institute (GB)
- NHS Lothian (GB)
- University of Liverpool (GB)
- Queen Mary University of London (GB)
- King's College London (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Central and North West London NHS Foundation Trust (GB)
- Wellcome Sanger Institute (GB)
- Innovate UK (GB)
- Open Targets (GB)
- BenevolentAI (United Kingdom) (GB)
- Genomics England (GB)
- William Harvey Research Institute (GB)
- NHS England
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1200/jco.23.02761
- Citations
- 11
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 5.14
Funders
- Wellcome Trust
- Cancer Research UK
- National Institute for Health and Care Research
- Medical Research Council