Non-invasive Biofluorometirc Sensing and Imaging Analysis of Blood VOCs for Novel Wearable Sensor

Blood contains volatile biomarkers related to diseases and metabolism. We developed a biofluorometric gas sensor that measures acetone with high sensitivity and confirmed its significance in lipid metabolism and diabetes when applied to breath measurement. Furthermore, regarding transcutaneous gases that permeate through the skin from blood, a biofluorometric gas-imaging system for ethanol vapor as the target chemical was developed and analyzed the secretion dynamics of transcutaneous gases at each skin site, thus showing the stable release of blood-derived volatile markers from the ear canal. Based on the results, we have developed a headphone-type gas sensor and succeeded in continuous and stable transcutaneous gas measurement, thus indicating the future potential of a novel wearable biosensor for blood VOCs.