Mitochondrial respiratory complex II is altered in renal carcinoma
Our findings suggest that the state of CII, epitomized by its assembly and SDHB levels, deteriorates with the progressive severity of ccRCC. These observations hold the potential for stratification of patients with worse prognosis and may guide the exploration of targeted therapeutic interventions.
Authors
- Vladimír Bobek (ORCID: https://orcid.org/0000-0002-8974-3577)
- Federica Monaco (ORCID: https://orcid.org/0000-0002-9798-3589)
- Zuzana Bielčiková (ORCID: https://orcid.org/0000-0001-8434-9848)
- Kateřina Komrsková (ORCID: https://orcid.org/0000-0002-6837-2148)
- Petr Klézl
- Jaromı́r Novák (ORCID: https://orcid.org/0000-0001-5851-9399)
- Katarína Kološtová
- Jiřı́ Neužil (ORCID: https://orcid.org/0000-0002-2478-2460)
- Lory Santarelli (ORCID: https://orcid.org/0000-0003-1015-7098)
- Sarka Dvorakova
- Luca Volpini (ORCID: https://orcid.org/0000-0003-4830-8613)
- Štěpána Boukalová (ORCID: https://orcid.org/0000-0002-6478-4604)
- Katerina Hadrava Vanova (ORCID: https://orcid.org/0000-0002-8868-6013)
- Marco Tomasetti (ORCID: https://orcid.org/0000-0001-5036-7052)
- Vojtěch Fiala (ORCID: https://orcid.org/0000-0002-4764-2399)
- Renata Zobalová (ORCID: https://orcid.org/0000-0002-9097-4700)
- Ondrej Sanovec (ORCID: https://orcid.org/0000-0003-3040-6602)
- Josef Včelák (ORCID: https://orcid.org/0000-0002-6546-0580)
- Karel Pacák
- Sona Miklovicova
Institutions
- Griffith University (AU)
- Marche Polytechnic University (IT)
- National Institutes of Health (US)
- Czech Academy of Sciences (CZ)
- Charles University (CZ)
- Czech Academy of Sciences, Institute of Biotechnology (CZ)
- Krajská Zdravotní (CZ)
- Institute of Endocrinology (CZ)
- Czech Academy of Sciences, Institute of Molecular Genetics (CZ)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- University Hospital Kralovske Vinohrady (CZ)
- General University Hospital in Prague (CZ)
- AGH University of Krakow (PL)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1016/j.bbadis.2024.167556
- Citations
- 5
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.43