Mitochondrial respiratory complex II is altered in renal carcinoma

Our findings suggest that the state of CII, epitomized by its assembly and SDHB levels, deteriorates with the progressive severity of ccRCC. These observations hold the potential for stratification of patients with worse prognosis and may guide the exploration of targeted therapeutic interventions.

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Publication Details

Journal
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Published
2024-10-31
DOI
https://doi.org/10.1016/j.bbadis.2024.167556
Citations
5
Primary Topic
Cancer, Hypoxia, and Metabolism
Type
article
Field-Weighted Citation Impact
1.43
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article

Mitochondrial respiratory complex II is altered in renal carcinoma

Vladimír Bobek, Federica Monaco, Zuzana Bielčiková, Kateřina Komrsková et al.
5 citations
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Cancer, Hypoxia, and Metabolism
1.43
article

Mitochondrial respiratory complex II is altered in renal carcinoma

Vladimír Bobek, Federica Monaco, Zuzana Bielčiková, Kateřina Komrsková, Petr Klézl, Jaromı́r Novák, Katarína Kološtová, Jiřı́ Neužil, Lory Santarelli, Sarka Dvorakova, Luca Volpini, Štěpána Boukalová, Katerina Hadrava Vanova, Marco Tomasetti, Vojtěch Fiala, Renata Zobalová, Ondrej Sanovec, Josef Včelák, Karel Pacák, Sona Miklovicova
article en
5 citations

Abstract

Our findings suggest that the state of CII, epitomized by its assembly and SDHB levels, deteriorates with the progressive severity of ccRCC. These observations hold the potential for stratification of patients with worse prognosis and may guide the exploration of targeted therapeutic interventions.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseVol. 1871(1)
Griffith University (AU), Marche Polytechnic University (IT), National Institutes of Health (US), Czech Academy of Sciences (CZ), Charles University (CZ), Czech Academy of Sciences, Institute of Biotechnology (CZ), Krajská Zdravotní (CZ), Institute of Endocrinology (CZ), Czech Academy of Sciences, Institute of Molecular Genetics (CZ), Eunice Kennedy Shriver National Institute of Child Health and Human Development (US), University Hospital Kralovske Vinohrady (CZ), General University Hospital in Prague (CZ), AGH University of Krakow (PL)
Good health and well-being
Openalex Percentile: Top 17%
Cancer, Hypoxia, and Metabolism
1.43
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