Disentangling the phenotypic patterns of hypertension and chronic hypotension
PairedPheWAS methods may open a phenome-wide path to disentangling hypertension and chronic hypotension. Our classifier provides a starting point for assigning individuals to BP-categories representing the upper, lower, and middle zones of the BP spectrum. 4.7 % of individuals matching 2017 BP categories for normal, elevated BP or isolated hypertension, have diastolic pressure < 60. Research is needed to fine-tune the classifier, provide external validation, evaluate the clinical significance of diastolic pressure < 60, and test the candidate hypotheses.
Authors
- Nunzia Bettinsoli Giuse (ORCID: https://orcid.org/0000-0002-7644-9803)
- Italo Biaggioni (ORCID: https://orcid.org/0000-0001-7667-7083)
- Lisa Bastarache
- William W. Stead (ORCID: https://orcid.org/0000-0002-5048-9540)
- Annette M. Williams (ORCID: https://orcid.org/0000-0002-2526-3857)
- Adam Lewis
Institutions
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of Biomedical Informatics
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1016/j.jbi.2024.104743
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vanderbilt University
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- U.S. National Library of Medicine
- National Center for Advancing Translational Sciences