Semaglutide Normalizes Increased Cardiomyocyte Calcium Transients in a Rat Model of High Fat Diet-Induced Obesity
While HFD increased cardiomyocyte [Ca<sup>2+</sup>]<sub>c</sub> transients and systolic sarcomere shortening, semaglutide normalized these alterations, mediated by reduced SR Ca<sup>2+</sup> load and LTCC currents. Because increased LTCC currents were previously traced to cardiac hypertrophy, these effects may explain why GLP-1-RAs provide benefits for patients with obesity with or without HFpEF, but rather adverse outcome in HFrEF.
Authors
- Alexander Nickel (ORCID: https://orcid.org/0000-0002-2562-0439)
- Anton Xu
- Martin Faßnacht (ORCID: https://orcid.org/0000-0001-6170-6398)
- David Weissman (ORCID: https://orcid.org/0000-0002-4579-0777)
- Ulrich Dischinger (ORCID: https://orcid.org/0009-0008-4885-9355)
- Vasco Sequeira (ORCID: https://orcid.org/0000-0002-9192-7674)
- Jan Dudek (ORCID: https://orcid.org/0000-0002-5672-7458)
- Marie Oertel
- Michael Kohlhaas (ORCID: https://orcid.org/0000-0001-6132-6037)
- Christoph Maack (ORCID: https://orcid.org/0000-0003-3694-4559)
- Julia Theisen
- Katharina J. Ermer
- Katharina Maria Ecker
Institutions
- Universitätsklinikum Würzburg (DE)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1002/ehf2.15152
- Citations
- 8
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Deutsche Forschungsgemeinschaft
- Julius-Maximilians-Universität Würzburg
- Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg