Photo‐Catalyzed Stereospecific Synthesis of Trisubstituted Alkenes Incorporating 3,3‐Difluoro‐<i>γ</i>‐Lactams from Morita‐Baylis‐Hillman Acetates and <i>N</i>‐Allylbromodifluoroacetamides
Abstract A photocatalytic methodology has been devised for the stereoselective construction of trisubstituted alkenes incorporating 3,3‐difluoro‐γ‐lactams in 17–93% yields via a radical cascade process utilizing MBH acetates and N ‐allylbromodifluoroacetamides as starting materials. The reaction mechanism involves single‐electron transfer, 5 ‐ exo ‐ trig cyclization, radical addition, and elimination in a cascade fashion.
Authors
- Xi Chen (ORCID: https://orcid.org/0000-0002-5807-4219)
- Jianwu Liu (ORCID: https://orcid.org/0000-0001-9009-8571)
- Hang‐Dong Zuo (ORCID: https://orcid.org/0009-0007-7969-0057)
- Yue Zhang (ORCID: https://orcid.org/0000-0002-3919-7037)
- Yuting Wang (ORCID: https://orcid.org/0000-0002-7267-4026)
- Jia‐Yin Wang (ORCID: https://orcid.org/0009-0002-3696-8657)
- Chi Ai
Institutions
- Changzhou University (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1002/adsc.202401103
- Citations
- 6
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- Changzhou University