Sex dimorphism and tissue specificity of gene expression changes in aging mice
There are clear sex differences in gene expression in aging across liver, muscle and white adipose. Core pathways, including amino acid metabolism, digestive system and lipid metabolism, contribute to sex differences in aging.
Authors
- David Sinclair (ORCID: https://orcid.org/0000-0002-9936-436X)
- Alice E. Kane (ORCID: https://orcid.org/0000-0002-4303-0491)
- Amber L. Mueller (ORCID: https://orcid.org/0000-0002-2842-1072)
- Judy Wu (ORCID: https://orcid.org/0000-0001-7040-4420)
- Dantong Zhu
- Brady Samuelson
- Matt Arnold
Institutions
- Harvard University (US)
- University of Washington (US)
- Institute for Systems Biology (US)
- Boston VA Research Institute (US)
- One Cell Systems (United States) (US)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1186/s13293-024-00666-4
- Citations
- 12
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- Glenn Foundation for Medical Research
- Fondation pour la Recherche Médicale
- National Institutes of Health
- National Institute on Aging