MORPHOLOGICAL SUBSTANTIATION OF THE EFFECTIVENESS OF PHOTODYNAMIC THERAPY IN CASE OF WIDESPREAD PERITONITIS IN AN EXPERIMENT

The article presents the results of experimental studies on the effects on the parietal and visceral peritoneum of intact animals and with simulated widespread peritonitis in white mongrel rats weighing 140 180 g. It was found that methylene blue at a concentration of 0.05% in intact animals at exposure of 5 minutes causes desquamation and small foci of necrosis of mesothelial cells, and in peritonitis against the background of photodynamic therapy has a beneficial effect on reparative processes due to the formation of singlet oxygen. The histological picture of the peritoneum in rats after abdominal sanitation by PDT at all stages of the study was qualitatively better than that of the representatives of the group during abdominal sanitation with 0.02% chlorhexidine solution. Based on the results of morphological studies, the authors recommend that the developed method of photodynamic sanitation of the abdominal cavity be introduced into clinical practice.