To evaluate the changes in Biochemical parameters of Breast cancer patients’ during treatment at Larkana Sindh.

Objective: To evaluate the changes in blood chemistry of breast cancer patients while under treatment at Larkana Institute of Nuclear Medicine and Radiotherapy (LINAR) Larkana, Sindh, Pakistan.Methodology: The present study was conducted on the two hundred Breast cancer patients and divided them in four groups on the basis of their treatment; age ranges between 20-70 years. Demographic characteristics of patients and blood samples were collected for biochemical parameters i.e., Electrolytes (Na+, k+, CI-, HCO3-), Calcium, Urea and Creatinine. Patients’ data was divided in groups on the basis of their treatment.Results: Present study focused on analysis of biochemical parameters of breast cancer patients during treatment. 36% of patients suffering from Breast cancer have been belonging to age group 41-50 years; whereas 11% risk was also found in age group 20-30 years which is highly alarming. Urea & Creatinine was found highly significantly increased in all groups; this is indication of poor blood flow to kidneys and threat of renal failure.Conclusion: Hyponatremia, hyperkalaemia, hypochloraemia and hypercalcemia was found in patients. Increased level of urea & creatinine is a big threat for renal failure in breast cancer patients. Chemotherapy with Radiotherapy and Surgery group was more prone to electrolytes imbalance. Keywords: Breast cancer, Chemotherapy, Radiotherapy, Electrolytes, Treatment.