Decitabine Enhances Sorafenib Sensitivity in Renal Cell Carcinoma by Promoting BIN1 and SYNE1 Expressions
SYNE1 contributes to the modulation of sorafenib resistance in ccRCC cells through interacting with BIN1. Decitabine treatment enhances expressions of these two proteins to improve TKI response, suggesting a potential strategy for counteracting resistance and bettering patient outcomes.
Authors
- Mengyun Jin
- Aixiao Xia
- Yuqin Mao (ORCID: https://orcid.org/0000-0001-6863-354X)
- Lijie Kang
Institutions
- Zhejiang Provincial People's Hospital (CN)
- Shaoxing People's Hospital (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-10-25
- DOI
- https://doi.org/10.31083/j.fbl2910370
- Citations
- 1
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.23