Diallyl Disulfide Mitigates Cadmium Hepatotoxicity by Attenuating Oxidative Stress and TLR-4/NF-κB Signaling and Upregulating PPARγ
DADS is effective against Cd-induced hepatotoxicity and its beneficial effects are linked to suppression of inflammation, OS and apoptosis and upregulation of PPARγ. DADS could be valuable to protect the liver in individuals at risk of Cd exposure, pending further studies to elucidate other underlying mechanism(s).
Authors
- Emad H. M. Hassanein (ORCID: https://orcid.org/0000-0003-4865-2342)
- Ayman M. Mahmoud (ORCID: https://orcid.org/0000-0003-0279-6500)
- Sulaiman Mohammed Alnasser (ORCID: https://orcid.org/0000-0001-8678-5029)
- Mohammed Alotaibi (ORCID: https://orcid.org/0000-0002-8754-3782)
- Reem S. Alruhaimi (ORCID: https://orcid.org/0000-0003-3746-8582)
- Omnia A. M. Abd El‐Ghafar
- Mohammed A. Alzoghaibi (ORCID: https://orcid.org/0000-0002-9036-4187)
- Mostafa K. Mohammad
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Beni-Suef University (EG)
- Manchester Metropolitan University (GB)
- Qassim University (SA)
- Al-Azhar University (EG)
- Nahda University (EG)
- King Saud University (SA)
- Assiut University (EG)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-10-23
- DOI
- https://doi.org/10.31083/j.fbl2910369
- Citations
- 3
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Princess Nourah Bint Abdulrahman University