HOXD9 Enhances the Release of HMGB1 and Boosts Glycolysis in Glioblastoma under Hypoxic Conditions, Leading to Tumor Growth by Activating the Transcription of PFKFB3
HOXD9 promoted hypoxia-induced HMGB1 secretion and glycolysis in GBM through the transcriptional activation of <i>PFKFB3</i>, which in turn promoted tumorigenesis.
Authors
- Guangzhi Xu (ORCID: https://orcid.org/0000-0001-8365-1404)
- Jingchi Sun
- Weiping Liu (ORCID: https://orcid.org/0009-0002-7224-5341)
- Lizhou Wei (ORCID: https://orcid.org/0000-0002-9079-0936)
- Xicai Yi
- Fuxin Han (ORCID: https://orcid.org/0009-0007-5856-7623)
Institutions
- Third People's Hospital of Chengdu (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-09-26
- DOI
- https://doi.org/10.31083/j.fbl2910341
- Citations
- 5
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China