RATIONALE FOR THE USE OF PRF, PRP, PDGF AND BMPS GROWTH FACTORS IN BONE TRANSPLANTS

Bone tissue has an unquestionable capacity to constantly renew itself and simultaneously regenerate.These processes are conducted through a complex cascade of biological events, influenced by various growth factors secreted by bone cells and reactive cells present at the site of injury.Growth factors are a class of natural biological agents that regulate the main cellular events involved in tissue repair, such as cell proliferation, chemotaxis, differentiation and matrix synthesis, through interaction with specific receptors on the cell surface.In the face of considerable bone loss, the field of implantology has several techniques for reconstructing bone tissue prior to the placement of dental implants.The scientific literature extensively details the advantages of autologous bone grafts over alloplastic and xenogenous bone grafts, due to their osteoinduction, osteoconduction and osteogenesis properties.Autologous bone grafts release a variety of molecules, including growth factors, which can direct the mesenchymal cells involved in bone regeneration.The aim of this study is to evaluate the clinical and histological outcomes of the growth factors PDGF and BMP and the platelet concentrates PRF and PRP in bone regeneration, taking into account in vitro, animal and human studies.To this end, searches were conducted for articles published in English or Portuguese in the Pub-Med and Medline databases, among others, using the terms "growth factors", "bone regeneration", "tissue engineering", "bone graft", "PRF", "PRP", "PDGF" and "BMPs".The literature review reveals that PDGF plays an important role in bone regeneration when combined with other materials, while BMPrh-2 improves and accelerates the bone regeneration process.On the other hand, PRP does not seem to favor significant results in bone regeneration, while PRF has shown promising results in bone regeneration in maxillary sinuses.However, more studies are needed to justify its use in implant dentistry clinical practice.