Perfusate Biomarkers of DCD Cardiac Graft Quality Identified With Proteomics: Studies in an Isolated Rat Heart Model
Multiple perfusate proteins, such as heat shock protein 70, valosin-containing protein, or glycogen phosphorylase, muscle associated, released during early reperfusion are promising as biomarkers for assessing graft quality during NMP. Perfusate proteins, as biomarkers, offer the possibility of both rapid immune detection and out-of-hospital implementation, and may provide valuable information about graft quality, especially when profiled with serial sampling during NMP.
Authors
- Alexia Clavier (ORCID: https://orcid.org/0009-0004-3682-8667)
- Rahel K. Wyss
- Maria Arnold (ORCID: https://orcid.org/0000-0003-4146-404X)
- Natalia Méndez‐Carmona
- Sarah Longnus (ORCID: https://orcid.org/0000-0001-8489-917X)
- Matthias Siepe (ORCID: https://orcid.org/0000-0003-3305-9343)
- Anne-Christine Uldry
- Adrian Segiser (ORCID: https://orcid.org/0009-0006-5796-1429)
- Manfred Heller (ORCID: https://orcid.org/0000-0002-6364-7325)
Institutions
- University of Bern (CH)
- University Hospital of Bern (CH)
Publication Details
- Journal
- Transplantation
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1097/tp.0000000000005241
- Citations
- 3
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 1.27