The Perspective Of Psoriasis In Bangladesh: Revealing Epidemiological Insights, Disease Severity, And The Impact On Quality Of Life From A Tertiary Hospital In Chittagong

Background: Psoriasis, an autoimmune disorder affecting the skin and joints, poses a significant global health concern, particularly in Bangladesh. The impact extends beyond physical symptoms, affecting mental and emotional well-being. Limited research in Bangladesh hampers a comprehensive understanding of psoriasis epidemiology, clinical profiles, and quality of life implications. This study aimed to address these gaps, emphasizing their impact on an individual's quality of life. Methods and materials: A cross-sectional observational study was conducted from January 2022 to October 2023 at Central Skin & Social Hygiene Center, a single Specialized Health Center in Chittagong, Bangladesh recruited 156 clinically and histopathologically diagnosed psoriasis patients. Data included socio-demographics, clinical profiles, Psoriasis Area and Severity Index (PASI) scores, and Dermatology Life Quality Index (DLQI) scores. Results: Among 156 enrolled patients, 147 completed the study, the mean age was 34.29 years, with ages ranging from 17 to 70 years. The male-to-female ratio of 1.77:1. The significant gender disparity in PASI scores (p = 0.035), indicates that hormones may play a role in the condition being studied. The majority (76.87%) of participants had mild psoriasis, and stress (30.61%) was a prevalent aggravating factor. Plaque psoriasis predominated (84.35%), followed by guttate (5.44%). A strong positive correlation (r = 0.7615, p < 0.001) between PASI and DLQI scores emphasized the impact of disease severity on quality of life. ANOVA results revealed a statistically significant difference in mean DLQI scores among the severity groups (F = 38.92, p < 0.001). Conclusion: This study contributes comprehensive insights into psoriasis in Bangladesh, emphasizing psychosocial dimensions, gender influences, and the strong correlation between disease severity and impaired quality of life. These findings inform tailored management approaches and support strategies for psoriasis patients in the region