Case Report: Steven Johnson Syndrome (SIS) Induced By Antibiotics: A Detailed Analysis

Background: Stevens-Johnson Syndrome SJS is a rare but very serious mucocutaneous disease primarily caused by medications that includes antibiotics. This case report is about a 35-year-old male who suffered from SJS due to treatment for urinary tract infection using co-trimoxazole. Case Presentation: The patient began with symptoms of flu, later on followed by rapid progression of erythematous rash and painful mucosal involvement. On clinical examination, there were blisters, skin detachment involving 10% of the body surface area, and oral and ocular mucosal lesions. This reaction developed in a temporal association with co-trimoxazole therapy, making the drug a likely cause. She was systemically treated with corticosteroids and supportive care and showed marked recovery in two weeks from hospitalization. Conclusion: This case underlines the importance of early suspicion of SJS in patients receiving antibiotic treatment. Removal of the offending drug and timely initiation of multi-disciplinary management will only improve the outcome in such patients.