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Background: Gallstones are a common gastrointestinal disorder often requiring cholecystectomy. Laparoscopic cholecystectomy, the gold standard for gallbladder removal, involves pneumoperitoneum (PNP) using carbon dioxide (CO2) for better visibility and access. However, postoperative shoulder pain remains a frequent complication, largely attributed to CO2 insufflation. This study compares the incidence and severity of postoperative shoulder pain between low-pressure pneumoperitoneum (LPP) and standard-pressure pneumoperitoneum (SPP) during laparoscopic cholecystectomy. Materials and Methods: A prospective interventional study was conducted at SMS Hospital, Jaipur, including 80 patients with gallstone disease undergoing elective laparoscopic cholecystectomy. Patients were divided into two groups: LPP (8–10 mm Hg) and SPP (12–14 mm Hg), each comprising 40 patients. Pain was assessed using the Verbal Rating Scale (VRS) at 2, 6, 12, 24, and 48 hours postoperatively. Data were analyzed using the unpaired two-tailed t-test, with a P value < 0.05 considered statistically significant. Results: The incidence of shoulder pain was significantly lower in the LPP group (10%) compared to the SPP group (40%) (P = 0.00). Mean VAS scores at 2, 6,12,24, and 48 hours post-surgery were consistently lower in the LPP group, with significant differences noted at each time point. At 12 hours, the LPP group had a mean VAS score of 0.62 ± 0.34 compared to 2.92 ± 1.4 in the SPP group (P = 0.00). By 48 hours, no LPP patients reported shoulder pain, whereas the SPP group still reported a mean VAS score of 0.62 ± 0.21 (P = 0.00). Conclusion: LPP is associated with significantly lower incidence and severity of postoperative shoulder pain compared to SPP in laparoscopic cholecystectomy. These findings suggest that LPP could be a better option for reducing patient discomfort and improving postoperative outcomes