Desipramine reverses remote memory deficits by activating calmodulin-CaMKII pathway in a <i>UTX</i> knockout mouse model of Kabuki syndrome
Our results reveal an epigenetic mechanism underlying the important role of <i>UTX</i> in synaptic plasticity and cognitive function, and suggest that desipramine could be a potential treatment for KS.
Authors
- Tatsuo Suzuki (ORCID: https://orcid.org/0000-0002-3537-5940)
- Yifang Kuang (ORCID: https://orcid.org/0000-0003-3361-7085)
- Charlie Degui Chen
- Eiki Takahashi (ORCID: https://orcid.org/0000-0002-0253-4968)
- Longyong Xu (ORCID: https://orcid.org/0000-0002-8574-4062)
- Zhaohui Lan
- Katsuhiko Tabuchi (ORCID: https://orcid.org/0000-0002-1673-4637)
- Ying Zhou (ORCID: https://orcid.org/0009-0006-9823-3460)
- Minggang Liu
- Qian Zhao (ORCID: https://orcid.org/0000-0003-4928-633X)
- Miou Zhou (ORCID: https://orcid.org/0000-0001-8188-7392)
- Yining Li (ORCID: https://orcid.org/0000-0002-4668-6373)
- Shuai Wang (ORCID: https://orcid.org/0000-0002-9252-7496)
- Lei Chen (ORCID: https://orcid.org/0000-0001-8113-0429)
- Weidong Li (ORCID: https://orcid.org/0000-0001-5384-4838)
- Xu Zhang (ORCID: https://orcid.org/0000-0003-2406-9478)
- Tian‐Le Xu
- Xiujuan Yang
Institutions
- Shinshu University (JP)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institutes for Biological Sciences (CN)
- Ministry of Science and Technology (VN)
- Drug Discovery Laboratory (Norway) (NO)
- Western University of Health Sciences (US)
Publication Details
- Journal
- General Psychiatry
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1136/gpsych-2023-101430
- Citations
- 1
- Primary Topic
- Genomics and Rare Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.55
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Shanghai Municipal Education Commission
- Natural Science Foundation of Chongqing
- Program of Shanghai Subject Chief Scientist
- Centers for Disease Control and Prevention
- National Key Research and Development Program of China
- National Science Fund for Distinguished Young Scholars
- David Geffen School of Medicine, University of California, Los Angeles