Soft Implantable Bioelectronics for the Management of Neurological Disorders and Cardiovascular Diseases

Continuous monitoring systems that effectively manage neurological disorders and cardiovascular diseases are crucial for enhancing the quality of life in aging societies. Soft implantable bioelectronics, which consists of soft devices with mechanical properties akin to biological tissues, are promising candidates for such monitoring systems. These devices enable conformal integration with target tissues, minimizing adverse side effects during their long-term use. They also precisely monitor physiological conditions, facilitating tailored therapeutic interventions based on individual physiological responses. This review highlights recent advancements in soft implantable bioelectronics for managing neurological disorders and cardiovascular diseases. Specifically, strategies for the materials, device fabrication, and their integration with the biological tissues are reviewed in detail first. Then, the challenges in translating these technologies into practical applications are addressed, including the integration of artificial intelligence (AI) technologies.