Prognostic Efficacy of the Albumin Grade in Patients with Hepatocellular Carcinoma.
We previously found that "albumin grade", formerly called the "ALBS grade," demonstrated significant capability for prognostic stratification in hepatocellular carcinoma (HCC) patients treated with lenvatinib. The purpose of the present study was to compare the performance of the albumin grade with that of the modified albumin-bilirubin (mALBI) grade in predicting overall survival of HCC patients with different BCLC stages and treatment types. We enrolled 7,645 Japanese patients newly diagnosed with HCC using the Akaike information criteria (AIC), likelihood ratio, and C-index in different Barcelona Clinic Liver Cancer (BCLC) stages and treatments. The albumin grade showed similar and slightly better performance than the mALBI grade for BCLC stage 0 and A and especially for patients who underwent curative surgery and ablation. In patients treated with transcatheter arterial chemoembolization, molecular targeted agents, and the best supportive care, the mALBI grade had better performance than the albumin grade. However, the differences of the indices were very small in all scenarios. Overall, the albumin grade was comparable in efficacy to the mALBI grade, showing particular benefit for patients with early-stage HCC.
Authors
- Kazuya Kariyama (ORCID: https://orcid.org/0000-0003-3996-7502)
- Hidenori Toyoda (ORCID: https://orcid.org/0000-0002-1652-6168)
- Kazuhiro Nouso (ORCID: https://orcid.org/0000-0002-2018-0008)
- Takeshi Hatanaka (ORCID: https://orcid.org/0000-0003-3656-285X)
- Shohei Shiota (ORCID: https://orcid.org/0009-0005-3104-385X)
- Atsushi Hiraoka (ORCID: https://orcid.org/0000-0003-1989-0480)
- Takashi Kumada (ORCID: https://orcid.org/0000-0003-2211-495X)
- Takuya Nagano (ORCID: https://orcid.org/0000-0003-1043-8033)
- Ei Itobayashi (ORCID: https://orcid.org/0000-0003-0475-2819)
- Toshifumi Tada (ORCID: https://orcid.org/0000-0002-0976-6761)
- Atsushi Naganuma (ORCID: https://orcid.org/0000-0003-0663-0102)
- Akemi Tsutsui (ORCID: https://orcid.org/0000-0003-2978-2723)
- Toru Ishikawa (ORCID: https://orcid.org/0000-0002-5470-9694)
- Akiko Wakuta (ORCID: https://orcid.org/0009-0005-6178-6769)
- Koichi Takaguchi (ORCID: https://orcid.org/0000-0003-0175-8721)
- Michitaka Imai (ORCID: https://orcid.org/0000-0001-6448-6036)
- Satoru Kakizaki (ORCID: https://orcid.org/0000-0003-0224-7093)
- Yuichi Hirano (ORCID: https://orcid.org/0000-0002-2946-3813)
- Satoshi Yasuda (ORCID: https://orcid.org/0000-0002-2266-2414)
- Noritomo Shimada
- Shinichiro Nakamura
- Kunihiko Tsuji
Institutions
- Niigata Cancer Center Hospital (JP)
- Saiseikai Niigata Daini Hospital (JP)
- National Hospital Organization Takasaki Medical Center (JP)
- Ogaki Municipal Hospital (JP)
- Gunma Saiseikai Maebashi Hospital (JP)
- Himeji Red Cross Hospital (JP)
- Teine Keijinkai Hospital (JP)
- Asahi General Hospital (JP)
- Ehime Prefectural Central Hospital (JP)
- Kagawa Prefectural Central Hospital (JP)
- Otemae Hospital (JP)
- Gifu Kyoritsu University (JP)
Publication Details
- Journal
- PubMed
- Published
- 2024-10-01
- DOI
- https://doi.org/10.18926/amo/67662
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00