Biomarkers to Predictive Modeling: Leveraging Feature Selection and Ensemble Learning for Ovarian Cancer Prognosis

Treatment outcomes and patient survival rates are greatly improved by early identification of ovarian cancer. However, to increase diagnostic accuracy, effective predictive modeling is required due to the biomarkers' variability and complexity. This research proposes a complex methodology that combines feature selection and ensemble learning approaches to create a forecast model for the diagnosis of ovarian cancer. Recursive feature elimination (RFE), a thorough feature selection technique, was originally used to identify important biomarkers in order to lower dimensionality and improve model interpretability. We then used ensemble learning techniques, which fuse together several machine learning models, to boost the prognosis's stability and predictive performance. Using a dataset containing clinical and genetic data from ovarian cancer patients, ensemble techniques called Adaboost, Catboost, Random Forest, and Gradient boosting were put into practice and validated. Performance metrics like precision, accuracy, F1-score, recall and AUC-ROC curve were used to measure the techniques' efficacy. The findings show that our approach not only performs better than conventional single-predictor models, with results that are roughly 99% correct, but it also offers important insights into the biomarkers which are most symptomatic of the course of ovarian cancer.