Calcium(II)‐Catalyzed Synthesis of Sulfoximinocyclopentenones
Abstract A series of 4‐sulfoximinocyclopent‐2‐en‐1‐ones was prepared in 35 to 99% yield through a calcium(II)‐catalyzed aza‐Piancatelli reaction, including in enantioenriched form. Depending on their substitution pattern, diverse diastereoselective chemical transformations can be applied to these scaffolds, allowing access to cyclopentane derivatives. This study opens synthetic routes to cyclopentane‐based scaffolds and also paves the way for the exploration of the associated chemical space in drug discovery.
Authors
- Christophe Bour (ORCID: https://orcid.org/0000-0001-6733-5284)
- Nicolas George (ORCID: https://orcid.org/0000-0002-0773-9225)
- Emilie Kolodziej
- Aurélien Alix (ORCID: https://orcid.org/0000-0002-9529-099X)
- Vincent Gandon (ORCID: https://orcid.org/0000-0003-1108-9410)
- Régis Guillot (ORCID: https://orcid.org/0000-0002-9003-0670)
- Xiangmeng Chen
Institutions
- Université Paris-Sud (FR)
- Centre National de la Recherche Scientifique (FR)
- Arkema (France) (FR)
- Université Paris-Saclay (FR)
- STMicroelectronics (France) (FR)
- Institut de Chimie Moléculaire et des Matériaux d'Orsay (FR)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1002/adsc.202401085
- Citations
- 2
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.50