Protective role of <i>SIRT1</i> (rs3758391 T > C) polymorphism against T2DM and its complications: Influence on GPx activity
Our findings suggest a protective role for <i>SIRT1</i> C allele against T2DM and diabetic neuropathy and diabetic retinopathy. We found in the presence of this allele the GPx activity increased. Also, we detected an enhanced oxidative stress level among overweight and obese patients with diabetes and its complications that could be involved in the pathogenesis of the disease.
Authors
- Rozita Naseri (ORCID: https://orcid.org/0000-0002-5724-3455)
- Kheirollah Yari (ORCID: https://orcid.org/0000-0002-8592-7651)
- Zohreh Rahimi (ORCID: https://orcid.org/0000-0001-7589-3307)
- Farnaz Khalili
- Mansour Rezaei (ORCID: https://orcid.org/0000-0002-6446-7289)
Institutions
- Kermanshah University of Medical Sciences (IR)
Publication Details
- Journal
- Health Science Reports
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1002/hsr2.70106
- Citations
- 1
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- Kermanshah University of Medical Sciences