Bioactivity Modulation: Anionic Influence on Cu(II) Schiff Base Complexes

ABSTRACT This article explains the synthesis of three Schiff base Cu(II) complexes derived from 3‐hydroxybenzaldehyde and ethylenediamine using three distinct copper anionic salts, and it explores the effects of those salts on the properties of the complexes. Elemental analysis, electronic spectra, FT‐IR, ESR, molar conductance, magnetic measurement, thermogravimetric analysis and PXRD were used to characterize the compounds. The anionic salt has been demonstrated to exhibit distinctive characteristics on Gram‐positive and Gram‐negative bacteria in terms of structure, DNA binding, cell viability, DNA breakage and activity. Furthermore, this ligand L 1 and its derivatives indicated positive antifungal efficacy against Aspergillus niger and Trichophyton tonsurans . The study elucidates the manner in which distinct anion salts impacted the properties of complexes and their antifungal, anticancer and antibacterial outcomes.