Construction of a lung cancer 3D culture model based on alginate/gelatin micro-beads for drug evaluation
These findings suggest that the 3D hydrogel cell culture models more closely mimicked the <i>in vivo</i> biological and clinical behavior of cells, and demonstrated higher innate resistance to anti-cancer drugs than the 2D cell culture models, and thus could serve as valuable tools for diagnosis, drug screening, and personalized medicine.
Authors
- Xiaoqi Feng (ORCID: https://orcid.org/0000-0002-3421-220X)
- Shuisheng Chen
- Huijuan Wu (ORCID: https://orcid.org/0000-0003-0069-1553)
- Kejing Tang
- Ziying Zhao
- Cong Ma (ORCID: https://orcid.org/0000-0003-2532-0038)
- Zhong Zhen Guan (ORCID: https://orcid.org/0000-0003-4808-7400)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Yong Dong (ORCID: https://orcid.org/0000-0002-9575-2998)
- L. Lei (ORCID: https://orcid.org/0000-0002-7770-2372)
- Yubo Tang
Institutions
- Sun Yat-sen University (CN)
- Guangdong Medical College (CN)
- Dongguan People’s Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2024-10-01
- DOI
- https://doi.org/10.21037/tlcr-24-490
- Citations
- 7
- Primary Topic
- 3D Printing in Biomedical Research
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- Natural Science Foundation of Guangdong Province