Association between severity of Nonalcoholic fatty liver and left ventricular diastolic dysfunction assessed by tissue Doppler echocardiography

Background: Numerous metabolic risk factors are shared by a wide range of cardiac problems that may be linked to nonalcoholic fatty liver disease (NAFLD). The purpose of this study was to determine if tissue Doppler echocardiography-measured left ventricular (LV) diastolic dysfunction and nonalcoholic fatty liver disease are related. Methods: In this prospective cross-sectional investigation, 92 NAFLD patients were involved and were divided according to Transabdominal ultrasound into three groups: GroupⅠ (grade I fatty liver) included 27 patients, Group Ⅱ (grade II fatty liver) included 29 patients and group Ⅲ (grade III fatty liver) included 36 patients. All patients underwent transabdominal ultrasound and measuring tissue Doppler transthoracic echocardiography e septal velocity, E/e, E/A ratio, peak E-wave velocity, and peak A-wave velocity. Results: Regarding echocardiographic functions, there was a statistical significant difference in the NAFLD degrees between the three groups; group III had higher E/A, E/e' ratio, and LA. While A and e' levels were higher among group I when compared with the other groups. E/e' ratio was positively associated with NAFLD grades, while positively associated with HTN. HTN, NAFLD, TC and LA can be used as independent factors for predicting diastolic dysfunction among the studied groups. Conclusion: In asymptomatic patient there was a significant association between NAFLD and cardiac diastolic dysfunction as NAFLD grades were associated with E/e' ratio (diastolic dysfunction).