Botulinum toxin versus mesotherapy on enhancement of facial scarring (A Controlled Randomized Clinical Trial)

Background: Most of the body’s tissues can undergo wound repair following a disruption of tissue integrity. Upon healing, these wounds result in scar formation. Botulinum Toxin A (BTA) is known to prevent fibroblast proliferation and it also induces temporary muscle paralysis. Also, mesotherapy is the non-invasive transdermal injection which can aid the skin to increase collagen and elastin production. Thus, both techniques are eligible for enhancement of facial scars.Aim of this study: The study was proposed to compare between the efficacy of early postoperative Botulinum Toxin type A (BTA) injection and mesotherapy growth factor AQ recovery serum on the scar appearance.Materials and methods: Thirty-three patients requiring treatment of facial scars by primary closure were selected for this study and were randomly distributed into three groups. Group A(n=11) received BTA injection while group B (n=11): received mesotherapy growth factor serum with a derma pen injection. Both groups received the injections within a period of 5 days after primary closure. Group C (n=11) the control group where no further treatment was given after primary closure. Follow-up of the patients was at 1, 3 and 6 months postoperatively to evaluate the wound scar enhancement using Vancouver scar scale (VSS) Scores and wound width, in addition to clinical photographs. Results: Results were statistically analyzed and compared using the IBM Statistical Package for Social Science (SPSS) software version 22.0.Conclusion: It can be concluded from this research that both BTA injection and mesotherapy using the micro-needling technique, offered exquisite outcomes on facial scars