Synthesis, Characterization and Antimicrobial Evaluation of Biphenyl derivatives against C. albicans and E. coli

Biphenyls are polynuclear aromatic hydrocarbons with a molecular formula (C12 H10) having more than one aromatic nucleus. Biphenyl derivatives substituted with an aromatic or heteroaromatic radical have therapeutic use in pharmaceutical compositions intended for use in humans or cosmetic compositions. The present study included the synthesis of biphenyls derivatives and their antifungal and antimicrobial activities. Four different compounds (SCPD1-SCPD4) were synthesized via different synthesis methods. All the compounds were characterized by different methods like TLC, IR, and NMR. All the peaks and spectra revealed the presence of synthesized compounds. Among all the synthesized compounds, SCPD3 has shown maximum activity against gram-negative E. coli, and SCPD4 has shown maximum activity against C. albicans when compared with standard drug ketoconazole. The series of biphenyl derivatives may be a potent alternative to some other antibacterial and antifungal agents.