Integrated Small Intestine Microbiota and Serum Metabolomics Reveal the Potential Mechanisms of Wine Steaming in Alleviating Rhubarb-Induced Diarrhea
PRH alleviated RH-induced diarrhea by recovering GM balance, reducing ZO-1 and occludin expression, and decreasing the release of inflammatory factors. This mechanism may be linked to the reduced anthraquinone content. This study is the first to explore the mechanism of wine steaming in alleviating RH-induced diarrhea through small intestinal flora and serum metabolomics. It provides data to support the broader clinical use of RH and its safer application.
Authors
- Chongbo Zhao (ORCID: https://orcid.org/0000-0001-9481-1418)
- Yuping Tang (ORCID: https://orcid.org/0000-0002-1272-057X)
- Yaya Bai
- Shi‐Jun Yue (ORCID: https://orcid.org/0000-0003-2097-223X)
- Qiao Zhang (ORCID: https://orcid.org/0009-0002-1135-339X)
- Zhang Li (ORCID: https://orcid.org/0000-0001-7936-3864)
- Rui Tian (ORCID: https://orcid.org/0000-0003-2570-4322)
- Yan Qian (ORCID: https://orcid.org/0000-0003-2108-703X)
- Yong-Gang Yan (ORCID: https://orcid.org/0000-0002-1287-0260)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Hebei University of Chinese Medicine (CN)
- Suzhou Research Institute (CN)
- Shaanxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-10-01
- DOI
- https://doi.org/10.2147/jir.s479654
- Citations
- 5
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.17