Neuroprotective Activity of Polyherbal Formulation on Colchicine Induced Alzheimer’s Disease in Rat Model

Objective: The current study was designed to study the neuroprotective effect of Polyherbal formulation against the Colchicine-induced Alzheimer’s disease rat model. Methods: The memory enhancing activity of Polyherbal formulation was demonstrated by the intracerebroventricular administration of colchicine in Sprague-dawley rats. The effect of Polyherbal formulation were studied by evaluating the neurobehavioral assessment parameters like Morris water maze test, Locomotor activity, Open filed and Elevated plus maze test were performed at 0, 7, 14 and 28 days for assessing the cognitive and gross behavioral activities in all groups. Results and Discussion: The effect of Polyherbal formulation shows a neuroprotective activity with significant (p<0.001) decrease in Mean transfer latency, Time spent in open arm, Number of entries in open arm, escape latency, number of ambulatory movement, latency, numbering of rearing, number of grooming, rest and significant (p<0.001) increase in time spent closed arm, number of entries in closed arm, Probe trail, time spent in platform quadrant and spontaneous locomotion, number of ipsilateral rotation. Conclusion: In conclusion, the result of current study evidenced that the Polyherbal formulation (PHF) showed potent neuroprotective activity against colchicine induced Alzheimer’s disease.