Computational Study of Aminoglycoside and Fluoroquinolone Antibiotics

Molecular Docking has become an important component of the drug discovery process. Since first being developed in the 1980s, advancements in the power of computer hardware and the increasing number of and ease of access to small molecule and protein structures have contributed to the development of improved methods, making docking more popular in both industrial and academic settings. In this research Molecular Docking performed on Ciprofloxacin and Streptomycin by using Auto dock and Discovery Studio Software. QSAR study revealed that substitution of different electron donating or withdrawing group at different position on Ciprofloxacin and Streptomycin. Lead nucleus elaborate change in pharmacological activity. Molecular docking done by substituting or replacing different group at different position affected the potency of drug. On addition of methyl and nitro group decreases the activity of Ciprofloxacin while replacement of Guanidino groups from streptidine ringincreases its antibiotic activity.