Marital dissolution and cognition: The mediating effect of Aβ neuropathology
Findings suggest that stressful life events, such as the dissolution of one's marriage, might exert an effect on Alzheimer's disease proteinopathy, which may subsequently influence poor cognition.<b>Highlights:</b> Marital dissolution was associated with increased amyloid beta (Aβ) and memory declines.Aβ burden mediated associations between marital dissolution and memory.Findings were robust to potential non-linear influences of age.Mediation results were not observed when stratifying marital groups by sex.
Authors
- Petroula Proitsi (ORCID: https://orcid.org/0000-0002-2553-6974)
- Rifah Anjum
- Avinash Chandra (ORCID: https://orcid.org/0009-0005-5072-7499)
- Laura Smith (ORCID: https://orcid.org/0000-0003-3275-1530)
- Sheena Waters (ORCID: https://orcid.org/0000-0001-7241-2272)
- Charles R. Marshall (ORCID: https://orcid.org/0000-0002-8227-2354)
Institutions
- Queen Mary University of London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/dad2.70032
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- Foundation for the National Institutes of Health
- Yale University
- Vanderbilt University
- University of Pennsylvania
- Ohio State University
- NYU Langone Medical Center
- Northwestern University
- Johns Hopkins University
- University of Texas Southwestern Medical Center
- University of Pittsburgh
- University of Rochester
- Rush University
- University of South Florida
- Vanderbilt University Medical Center
- York University
- Jewish General Hospital
- National Institutes of Health
- University of California, Los Angeles
- University of California, San Diego
- Medical School, University of Michigan
- Wake Forest School of Medicine
- Canadian Institutes of Health Research
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering