Integrating network pharmacology, molecular docking, and experimental validation to reveal the mechanism of Radix Rehmanniae in psoriasis
In summary, RR is featured with multicomponent, multi-target, and multi-pathway in treating psoriasis; the preliminary mechanism may be associated with the down-regulation of p38MAPK phosphorylation and curbing the expression of inflammatory factor by aucubin. This paper provides the scientific basis for Traditional Chinese medicine treating psoriasis.
Authors
- Nian Mo (ORCID: https://orcid.org/0009-0004-1829-3793)
- Chuanjian Lu (ORCID: https://orcid.org/0000-0001-6531-0702)
- Panyu Zhou
- Fanlu Liu (ORCID: https://orcid.org/0009-0002-6779-6640)
- Ling Han
- Haojie Su
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Weatherford College (US)
- Key Laboratory of Guangdong Province (CN)
- Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality (CN)
Publication Details
- Journal
- Medicine
- Published
- 2024-10-25
- DOI
- https://doi.org/10.1097/md.0000000000040211
- Citations
- 5
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.81
Funders
- Guangzhou Municipal Science and Technology Project