Exploring the Prevalence and Prognostic Impact of Wilms Tumor 1 Exon 7 Mutation Status with Combinations of FLT3-ITD and NPM1 Mutations as Potential Molecular Biomarkers in Acute Myeloid Leukemia Patients with Normal Cytogenetics
This study found a significant association between patient survival outcomes and NPM1 mutation status, as well as the combined FLT3-ITD and NPM1 status. Profiling both NPM1 and FLT3-ITD mutations at the time of diagnosis serves as a robust prognostic marker in AML treatment. WT1 mutation status did not show a significant association with patient outcomes. Larger population studies may provide more relevant insights.
Authors
- Jagathnath Krishna Kumarapillai Mohanan Nair
- Akhila Raj Thampirajan Vimala Devi
- Sankar Surendran (ORCID: https://orcid.org/0000-0003-1430-5393)
- Geetha Raj John Anitha
- Mahitha Mohanan Sreelatha
- Amritha Padmakumar
- Devipriya Padmakumar
- Vineetha Radhakrishnan Chandraprabha
- Geetha Narayanan (ORCID: https://orcid.org/0000-0002-0345-6623)
- Preethi Gopinath (ORCID: https://orcid.org/0000-0003-0619-4881)
- Hariharan Sreedharan
Institutions
- Regional Cancer Center, Thiruvananthapuram (IN)
Publication Details
- Journal
- Asian Pacific Journal of Cancer Prevention
- Published
- 2024-10-01
- DOI
- https://doi.org/10.31557/apjcp.2024.25.10.3463
- Citations
- 2
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 1.09
Funders
- Kerala State Council for Science, Technology and Environment