Copper Overload Promotes β-amyloid Induced NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis in Alzheimer’s Disease
Exposure to copper ions disrupt mitochondrial copper homeostasis, promotes Aβ aggregation, and activates NLRP3 inflammasomes, further promoting the Aβ aggregation activated pyroptosis in AD cell models.
Authors
- Mingming Zhu (ORCID: https://orcid.org/0000-0002-1319-5199)
- Changpeng Wang (ORCID: https://orcid.org/0000-0001-8603-9704)
- Ling Zhang (ORCID: https://orcid.org/0009-0005-5935-5097)
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Shanghai Xuhui Central Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Journal of Integrative Neuroscience
- Published
- 2024-10-21
- DOI
- https://doi.org/10.31083/j.jin2310194
- Citations
- 18
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.88