Decrease of Prolylcarboxypeptidase Dose of Aqueous Humor is Involved in the Pathogenesis of Primary Open-Angle Glaucoma via Finetuning of the Local Ocular Renin-Angiotensin System
Our study found PRCP dose was decreased in POAG patients' aqueous humor, and it might cause high level of AngII. Restoration of PRCP rescued fibrosis of TM cells and ameliorated IOP in AngII treatment mouse.
Authors
- Huiling Cui (ORCID: https://orcid.org/0000-0001-9203-5072)
- Yihan Liu (ORCID: https://orcid.org/0009-0004-4717-2966)
- Bo Tang (ORCID: https://orcid.org/0000-0002-1369-9645)
- Yuanyuan Xiao (ORCID: https://orcid.org/0000-0003-2441-7209)
- Shichao Duan (ORCID: https://orcid.org/0000-0002-3177-4194)
- Rick F. Thorne (ORCID: https://orcid.org/0000-0001-7882-7081)
- Rumeng Zhao
- Yuhao Wang (ORCID: https://orcid.org/0000-0002-8445-0361)
- Jing Wang (ORCID: https://orcid.org/0009-0009-5884-842X)
- Di Wang (ORCID: https://orcid.org/0000-0001-5036-7909)
- Shichao Zhu (ORCID: https://orcid.org/0000-0003-3154-8901)
- Xinyuan Hu (ORCID: https://orcid.org/0000-0002-7443-1474)
- Zhongqiang Guo
- Jing Ren (ORCID: https://orcid.org/0000-0001-5778-4676)
- Huaying Wang
- Gang Wang (ORCID: https://orcid.org/0000-0001-9318-6251)
Institutions
- Army Medical University (CN)
- Henan University (CN)
- Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
- Henan Provincial Eye Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Huanghe Science and Technology College (CN)
Publication Details
- Journal
- Dose-Response
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1177/15593258241298062
- Citations
- 1
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Henan Province