Novel metabolomic predictors of incident colorectal cancer in men and women
We identified prediagnostic CRC-associated metabolites with distinct sex-specific profiles. These results provide insight into CRC etiopathogenesis and have implications for risk prediction strategies.
Authors
- A. Heather Eliassen (ORCID: https://orcid.org/0000-0002-3961-6609)
- Mingyang Song (ORCID: https://orcid.org/0000-0002-1324-0316)
- Jeffrey A. Meyerhardt (ORCID: https://orcid.org/0000-0002-1120-0898)
- Edward L. Giovannucci (ORCID: https://orcid.org/0000-0002-6123-0219)
- Alaina M. Bever (ORCID: https://orcid.org/0000-0003-3004-8497)
- Amit D. Joshi (ORCID: https://orcid.org/0000-0001-7581-6934)
- David A. Drew (ORCID: https://orcid.org/0000-0002-8813-0816)
- Rulla M. Tamimi (ORCID: https://orcid.org/0000-0003-2306-8668)
- Charles S. Fuchs (ORCID: https://orcid.org/0000-0003-1582-9842)
- Peter Kraft (ORCID: https://orcid.org/0000-0002-4472-8103)
- Clary B. Clish (ORCID: https://orcid.org/0000-0001-8259-9245)
- Oana A. Zeleznik (ORCID: https://orcid.org/0000-0002-8705-1163)
- Connor M. Geraghty
- Fred K. Tabung (ORCID: https://orcid.org/0000-0001-8193-7150)
- Andrew T. Chan (ORCID: https://orcid.org/0000-0001-7284-6767)
- Brendan J. Guercio (ORCID: https://orcid.org/0000-0001-6296-2473)
- Kana Wu (ORCID: https://orcid.org/0000-0001-7300-1694)
- Jonathan M. Downie (ORCID: https://orcid.org/0000-0002-5424-4401)
- Walter Churchill Willett (ORCID: https://orcid.org/0000-0003-1458-7597)
- Xuehong Zhang (ORCID: https://orcid.org/0000-0002-8260-8508)
- Lina Jin (ORCID: https://orcid.org/0000-0002-8961-2809)
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Cornell University (US)
- Yale Cancer Center (US)
- Yale University (US)
- Massachusetts General Hospital (US)
- Dana-Farber Cancer Institute (US)
- Weill Cornell Medicine (US)
- The Ohio State University (US)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2024-10-28
- DOI
- https://doi.org/10.1093/jnci/djae270
- Citations
- 7
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- National Institutes of Health
- Centers for Disease Control and Prevention
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases