Effects of positive mGlu5 modulation on D<sub>2</sub> signaling and nicotine-conditioned place preference: Mechanisms of epigenetic inheritance in a transgenerational model of drug abuse vulnerability in psychosis
These results reveal an important region-specific mechanism of action for CDPPB in a system marked by enhanced DAD<sub>2</sub> receptor signaling. Results additionally reveal DNA methylation as an epigenetic mechanism of heritability, further validating the current model as a useful tool for the study of psychosis and comorbid nicotine use.
Authors
- Susan Christine Massey (ORCID: https://orcid.org/0000-0002-4680-7796)
- Russell W. Brown (ORCID: https://orcid.org/0000-0002-6512-7315)
- Wanqiu Chen (ORCID: https://orcid.org/0000-0003-3706-7834)
- Loren D. Peeters (ORCID: https://orcid.org/0000-0001-8686-9150)
- Liza J. Wills (ORCID: https://orcid.org/0000-0003-1698-0448)
- Justin T. Gass (ORCID: https://orcid.org/0000-0002-6829-6261)
- Anthony M. Cuozzo
- Zhong Chen (ORCID: https://orcid.org/0000-0003-4755-9357)
- Charles Wang
- Cristal D. Ahmed
Institutions
- East Tennessee State University (US)
- Loma Linda University (US)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2024-10-27
- DOI
- https://doi.org/10.1177/02698811241292902
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.31
Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism
- National Institute on Drug Abuse
- National Institute of Neurological Disorders and Stroke